Felicia Ng


PhD-Student
University of Cambridge
Department of Haematology, Cambridge Institute for Medical Research & Wellcome Trust/MRC Cambridge Stem Cell Institute

Yousef Jameel Scholarship (Cambridge Commonwealth, European and International Trust)

Research Overview

Transcription factors (TFs) are important regulators of haematopoietic cell type identity. Specific TFs have been shown to be critical for regulating pluripotency genes in haematopoietic stem cells while others drive differentiation. In recent years, advances in the generation of TF binding maps by ChIP-seq permitted investigations at the genome level across different haematopoietic cell types. While an abundance of ChIP-seq data exists, not much is known about the genome-wide impact of TF binding in driving transcriptional programs of multiple cell types. The rules that govern functional TF binding are also not clearly understood but knowledge in this area is important for understanding the molecular mechanisms of transcription in haematopoietic differentiation. My research utilizes computational and statistical models of genome-wide binding events to make predictions on cell-type-specific transcriptional mechanisms.

Publications

More details here: Research Gate

Science in Pics

  • Client Name
  • Client Name
  • Client Name
  • Client Name
  • Client Name
  • Client Name
  • Client Name
  • Client Name