Overview of the HSCL

We use both experimental and computational approaches to study the transcriptional control of normal and leukaemic blood stem/progenitor cells.

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Selected Publications

01

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. 

                          Nature Cell Biology (2013)

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02

Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. 

                          Dev Cell (2011) 20(5): 597-609

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03

LIF independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. 

Nature Cell Biology (2011) 13(1): 13-21

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04

Combinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators. 

Cell Stem Cell (2010) 7(4):532-544

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Recent News

ChIP-Seq Data

ChIP-Seq Datafiles are available  here and here


T-ALL study

Information and forms now available here


Research Funding

We gratefully acknowledge the following funding agencies for their generous support:          Leukemia& Lymphoma Research, BBSRC, Medical Research Council, Cancer Research UK, Kay Kendall Leukaemia Fund, Leukemia and Lymphoma Society, EMBO, The Wellcome Trust, EU Marie Curie programme.

Last updated 30 October 2012